Interesting Cases

Diagnostic puzzles that educate and inspire

Case #2026-0847 Complex

The "Benign" Thyroid Nodule

A 34-year-old woman with a thyroid nodule read as "follicular lesion of undetermined significance" on FNA. The resection revealed an unexpected finding...

Age/Sex:34F
Specimen:Thyroid, total thyroidectomy
Key Stain:HBME-1, Galectin-3
Cytopathology Endocrine Teaching
Case #2026-0792 Very Complex

When Lymphoma Mimics Sarcoma

A soft tissue mass in a 67-year-old male initially favored pleomorphic sarcoma. Immunohistochemistry told a different story entirely...

Age/Sex:67M
Specimen:Soft tissue, excisional biopsy
Key Stain:CD30, ALK, Desmin
Hematopathology Soft Tissue Differential
Case #2026-0715 Complex

The Incidental Adrenal Mass

Found during workup for unrelated abdominal pain. Imaging suggested adenoma. Histology revealed a rare neuroendocrine tumor with unusual features...

Age/Sex:52F
Specimen:Adrenal gland, laparoscopic adrenalectomy
Key Stain:Synaptophysin, Chromogranin, Ki-67
Surgical Endocrine Rare
Case #2026-0654 Expert

Pediatric Brain Tumor: A Diagnostic Odyssey

A 4-year-old with a posterior fossa mass. Initial impression: medulloblastoma. Molecular profiling revealed an entirely different entity with critical treatment implications...

Age/Sex:4M
Specimen:Cerebellum, subtotal resection
Key Test:Methylation profiling, NGS panel
Neuropathology Pediatric Molecular